Study title

Persistent organic pollutants (POPs) are toxic and hazardous chemicals omnipresent in our environment and food chains. These pollutants are of particular public health concern since their bio-accumulate in humans for many years because of their resistance to metabolic degradation. Recently, exposure to POPs commonly found in food chains wa s found to contribute to insulin resistance and metabolic disorders like obesity, type 2 diabetes and nonalcoholic fatty liver disease. Yet, the molecular mechanisms by which POPs interact with insulin and impair glucose/lipid homeostasis remain relatively unexplored. In the present project, we will investigate the mechanims by which POPs may mediate their deleterious health effects.