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Summary information

Study title

Short-term outcomes of pubertal suppression in a selected cohort of 12 to 15 year old young people with persistent gender dysphoria in the UK 2019-2021

Creator

Carmichael, P, Tavistock and Portman NHS Foundation Trust
Butler, G, Tavistock and Portman NHS Foundation Trust
Masic, U, Tavistock and Portman NHS Foundation Trust
Cole, T, University College London
De Stavola, B, University College London
Davidson, S, Tavistock and Portman NHS Foundation Trust
Skageberg, E, Tavistock and Portman NHS Foundation Trust
Khadr, S, University College London
Viner, R, UCL Great Ormond St. Institute of Child Health

Study number / PID

854413 (UKDA)

10.5255/UKDA-SN-854413 (DOI)

Data access

Open

Series

Not available

Abstract

In adolescents with severe and persistent gender dysphoria (GD), gonadotropin releasing hormone analogues (GnRHa) are used from early/middle puberty with the aim of delaying irreversible and unwanted pubertal body changes. Evidence of outcomes of pubertal suppression in GD is limited. We undertook an uncontrolled prospective observational study of GnRHa as monotherapy in 44 12-15 year olds with persistent and severe GD. Prespecified analyses were limited to key outcomes: bone mineral content (BMC) and bone mineral density (BMD); Child Behaviour CheckList (CBCL) total t-score; Youth Self-Report (YSR) total t-score; CBCL and YSR self-harm indices; at 12, 24 and 36 months. Semi-structured interviews were conducted on GnRHa.

Topics

HealthSociety and culturePsychology

Keywords

GENDER ROLEADOLESCENT PSYCHOLOGYTRANSGENDERPUBERTYCHILD BEHAVIOURSELF HARMYOUTHSOCIOLOGY OF THE BODYBEHAVIOURLIFESTYLE AND BEHAVIOUR2021

Methodology

Data collection period

01/04/2011 - 28/02/2019

Country

United Kingdom

Time dimension

Not available

Analysis unit

Individual

Universe

Not available

Sampling procedure

Not available

Kind of data

Numeric
Text

Data collection mode

We undertook an uncontrolled prospective observational study of GnRHa as monotherapy in 44 12-15 year olds with persistent and severe GD. Prespecified analyses were limited to key outcomes: bone mineral content (BMC) and bone mineral density (BMD); Child Behaviour CheckList (CBCL) total t-score; Youth Self-Report (YSR) total t-score; CBCL and YSR self-harm indices; at 12, 24 and 36 months. Semi-structured interviews were conducted on GnRHa. During the recruitment period (April 2011- April 2014), there were 137 young people who were potentially eligible for the study; i.e. aged between 11 and 14.15 years and in the Tavistock service for over 6 months. Of these, 48 young people (35%) requested to be attend the UCLH clinics for information about and assessment for the study. 4 did not seek further involvement after the first appointment, leaving 44 young people taking part in the study.

Funding information

Grant number

Unknown

Access

Publisher

UK Data Service

Publication year

2021

Terms of data access

The Data Collection is available to any user without the requirement for registration for download/access.

Related publications

Not available