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EPIGENETICS
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Environmental DNA Methylation Signatures of Adolescent Victimization: Analysis of a Longitudinal Monozygotic Twin Sample, 2015-2020
Accumulating evidence suggests that individuals exposed to victimization at key developmental stages may have different epigenetic fingerprints compared to those exposed to no/minimal stressful events, however results are inconclusive. This study aimed to strengthen causal inference regarding the impact of adolescent victimization on the epigenome by controlling for genetic...
Gene expression omnibus: A biosocial systems approach to understanding the epigenetic embedding of social stress responses 2015-2018
Dysregulation of the Hypothalamo-Pituitary-Adrenal (HPA) Axis is a characteristic feature of the pathophysiology of depression, anxiety and post-traumatic stress disorder (PTSD), which result from chronic or extreme exposures to psychosocial stressors. A zebrafish mutant lacking Glucocorticoid Receptor (GR) function exhibits profound behavioural and endocrine abnormalities...
Genome-wide DNA methylation profiles across four UK population based cohorts 2015-2018
We obtained newly-generated genome-wide DNA methylation profiles from whole blood in 240 individuals from the TwinsUK cohort. DNA methylation levels were profiled at 38-86 years of age using the Infinium MethylationEPIC BeadChip. Epigenetic mechanisms such as DNA methylation are key regulators of gene function. Epigenetic signals are malleable and can change in response to...