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          <titl xml:lang="sv">Respiratory Health In Northern Europe</titl>
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      <abstract xml:lang="en">The Respiratory Health in Northern Europe (RHINE) is a follow-up study of participants from seven Northern European centres who participated in European Community Respiratory Health Survey (ECRHS) stage I. The target population for the RHINE study were all subjects (n=21,802) from Reykjavik in Iceland, Bergen in Norway, Umeå, Uppsala and Göteborg in Sweden, Aarhus in Denmark and Tartu in Estonia that participated in stage 1 of the ECRHS (response rate 83.7%). The eligible subjects were sent a postal questionnaire in 1999-2001. In total 16,191 (74.3%) subjects answered the questionnaire.This questionnaire includes questions on respiratory symptoms, asthma, rhinitis, bronchitis, smoking, indoor environment, occupation, early life exposure and sleep disorders.  Part of this population are part of the ECRHS II The ECRHS II is a follow-up survey of subjects from 14 countries who participated in the clinical phase of ECRHS I (3,4). The study is funded by the European Commission, as well as other sources of funding, as part of their Quality of Life Programme.The participants answered a detailed structured interview about symptoms, exposure to known or suspected risk factors for asthma, occupation and health service utilisation. Blood was taken for measurement of specific IgE to house dust mite, grass, cat and Cladosporium and DNA extraction (not all centres). Spirometry and methacholine challenge was performed. Health related quality of life was assessed by self completed questionnaires: SF-36 and AQLQ. In a sub-sample home visits were made to measure exposure to house dust mites and cat allergens. Throughout the study outdoor exposure to PM2.5, PM10 and NO2 was measured in the centres participating in the study.  A follow up of the RHINE and ECRHS populations was conducted in 2010-2012: RHINE III and ECRHS III  Purpose:  1. To assess the incidence and remission rate of asthma and allergic rhinitis and to      determine risk factors in a representative Nordic population sample.  2.  To assess the influence of occupational and home related environmental exposure      on the development of asthma and allergic rhinitis in Northern Europe.  3.  To investigate the association between the menstrual cycle and asthmatic      symptoms in women.  4.   To assess the incidence and remission of sleep disturbances and determine risk       factors including atopy and asthma.</abstract><abstract xml:lang="sv">The Respiratory Health in Northern Europe (RHINE) är en uppföljningsstudie av deltagare från sju nordeuropeiska center som deltog i European Community Respiratory Health Survey (ECRHS) steg I. Målgruppen för RHINE studien var alla deltagare (n = 21802 ) från Reykjavik på Island, Bergen i Norge, Umeå, Uppsala och Göteborg i Sverige, Århus i Danmark och Tartu i Estland som deltog i steg 1 i ECRHS (svarsfrekvens 83,7%). De utvalda deltagarna skickades en postenkät 1999-2001. Totalt svarade 16191 (74,3%) på den utskickade enkäten. Denna enkät innehåller frågor om luftvägssymptom, astma, rinit, bronkit, rökning, inomhusmiljö, yrkesexponering, exponering tidigt i livet och sömnstörningar.  En del av denna population ingår som en del av ECRHS II ECRHS II är en uppföljande studie av deltagare från 14 länder som deltog i den kliniska fasen av ECRHS I. Studien finansieras av Europeiska kommissionen, liksom andra finansieringskällor, som en del av deras Quality of Life Programme. Deltagarna besvarade en detaljerad strukturerad intervju om symptom, exponering för kända eller misstänkta riskfaktorer för astma, yrke och sjukvårds- utnyttjande. Blodprov togs för mätning av specifik IgE mot dammkvalster, gräs, katt och Cladosporium och DNA-extraktion (inte alla centra). Spirometri och metakolinbelastning utfördes. Hälsorelaterad livskvalitet bedömdes genom självbesvarade enkäter: SF-36 och AQLQ. I ett delprov gjordes hembesök för att mäta exponeringen mot kvalster och kattallergener. Under studien utomhus exponering för PM2,5, var PM10 och NO2 mätt i centra som deltar i studien.  En uppföljning av RHINE och ECRHS populationerna genomfördes under 2010-2012: RHINE III och ECRHS III  Syfte:  1. Att bedöma incidensen av och remissionsgrad för astma och allergisk rinit samt bestämma riskfaktorer i ett representativt nordiskt befolkningsurval.  2. Att bedöma inverkan av arbets- och hemrelaterade miljöexponering på utvecklingen av astma och allergisk rinit i norra Europa.  3. Att undersöka sambandet mellan menstruationscykeln och astmatiska symptom hos kvinnor.  4. Att bedöma incidensen av och remission av sömnproblem och bestämma riskfaktorer inklusive atopi och astma.</abstract>
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