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          <titl xml:lang="sv">Matrix Metalloproteinases vid kronisk obstruktiv lungsjukdom och åderförkalkning</titl>
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        <titl xml:lang="sv">Matrix Metalloproteinases vid kronisk obstruktiv lungsjukdom och åderförkalkning</titl>
        <parTitl xml:lang="en">Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking</parTitl>
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        <AuthEnty affiliation="Lund University and Region Skåne" xml:lang="en">Kraen, Morten
        </AuthEnty><AuthEnty affiliation="Lunds universitet och Region Skåne" xml:lang="sv">Kraen, Morten
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        <keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D050197">Atherosclerosis</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D050197">Ateroskleros</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D029424">Pulmonary Disease, Chronic Obstructive</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D029424">Kroniskt obstruktiv lungsjukdom</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D019278">Matrix Metalloproteinase 3</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D019278">Matrixmetalloproteinas 3</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D020781">Matrix Metalloproteinase 1</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D020781">Matrixmetalloproteinas 1</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D020783">Matrix Metalloproteinase 7</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D020783">Matrixmetalloproteinas 7</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D053506">Matrix Metalloproteinase 10</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D053506">Matrixmetalloproteinas 10</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D053508">Matrix Metalloproteinase 12</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D053508">Matrixmetalloproteinas 12</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D001161">Arteriosclerosis</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D001161">Arterioskleros</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008173">Lung Diseases, Obstructive</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008173">Lungsjukdomar, obstruktiva</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D017364">Collagenases</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D017364">Kollagenaser</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D053505">Matrix Metalloproteinases, Secreted</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D053505">Matrixmetalloproteinaser, utsöndrade</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008171">Lung Diseases</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008171">Lungsjukdomar</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D001157">Arterial Occlusive Diseases</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D001157">Pulsåderförträngning</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008666">Metalloendopeptidases</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008666">Metalloendopeptidaser</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D020782">Matrix Metalloproteinases</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D020782">Matrixmetalloproteinaser</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D036341">Intercellular Signaling Peptides and Proteins</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D036341">Intercellulära, signalöverförande peptider och proteiner</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D012140">Respiratory Tract Diseases</keyword><keyword xml:lang="sv" vocab="MeSH" 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Diseases</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D014652">Kärlsjukdomar</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D045726">Metalloproteases</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D045726">Metalloproteaser</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D002318">Cardiovascular Diseases</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D002318">Hjärt-kärlsjukdomar</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000602">Amino Acids, Peptides, and Proteins</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000602">Aminosyror, peptider och proteiner</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D010447">Peptide Hydrolases</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D010447">Peptidhydrolaser</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D006867">Hydrolases</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D006867">Hydrolaser</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D004798">Enzymes</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D004798">Enzymer</keyword><keyword xml:lang="en" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D045762">Enzymes and Coenzymes</keyword><keyword xml:lang="sv" vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D045762">Enzymer och koenzymer</keyword>
        <topcClas xml:lang="en" vocab="Standard för svensk indelning av forskningsämnen 2011">Clinical Medicine</topcClas><topcClas xml:lang="sv" vocab="Standard för svensk indelning av forskningsämnen 2011">Klinisk medicin</topcClas><topcClas xml:lang="en" vocab="Standard för svensk indelning av forskningsämnen 2011">Medical and Health Sciences</topcClas><topcClas xml:lang="sv" vocab="Standard för svensk indelning av forskningsämnen 2011">Medicin och hälsovetenskap</topcClas>
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      <abstract xml:lang="en">Matrix metalloproteinases (MMP´s) are known biomarkers of atherosclerosis. MMP´s are also involved in the pathophysiological processes underlying chronic obstructive pulmonary disease (COPD).  Cigarette smoking plays an important role in both disease states and is also known to affect the concentration and activity of MMP´s systemically. Unfortunately, the epidemiological data concerning the value of MMP´s as biomarkers of COPD and atherosclerosis with special regards to smoking habits are limited. Methods:  417  subjects with records of smoking habits and tobacco consumption were examined with comprehensive spirometry, carotid ultrasound examination and biomarker analysis of MMP-1, -3, -7, -10 and   -12</abstract><abstract xml:lang="sv">Mätning av blodnivå av Matrix Metalloproteinases vid kronisk obstruktiv lungsjukdom och åderförkalkning och rökning.</abstract>
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