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301ae75199dc0936df75591478aefa3544dd7ee047fa237d96a43c97e9b28050 2026-06-02T14:04:41Z language:svopenaire_data

Skillnad i metabola profiler mellan katter av raserna burma, maine coon och birma - tre raser med olika hög risk att utveckla diabetes mellitus - Information om friska katter av tre raser: burma, birma och maine coon. Data om katterna (ex ålder och vikt) samt hormonkoncentrationer i blodserum. Swedish National Data ServiceSvensk nationell datatjänst Landing page Skillnad i metabola profiler mellan katter av raserna burma, maine coon och birma - tre raser med olika hög risk att utveckla diabetes mellitus - Information om friska katter av tre raser: burma, birma och maine coon. Data om katterna (ex ålder och vikt) samt hormonkoncentrationer i blodserum. Differences in metabolic profiles between the Burmese, the Maine Coon and the Birman cat - three breeds with varying risk for diabetes mellitus - Information on healthy cats of three breeds; Burmese, Birman and Maine coon. Data on the cats (e.g. age and weight) and on serum blood concentrations. 2021-58-1-1https://doi.org/10.5878/7qsz-6j80 Ström Holst, Bodil Ström Holst, Bodil Öhlund, Malin Öhlund, Malin Moazzami, Ali Moazzami, Ali Mullner, Elisabeth Mullner, Elisabeth Anderson, Fredrick Anderson, Fredrick Swedish National Data ServiceSvensk nationell datatjänst 2021-04-06 Landing page Diabetes MellitusDiabetesHuman health and safetyMänniskors hälsa och säkerhetEndocrine System DiseasesHormonsjukdomarGlucose Metabolism DisordersGlukosomsättningsstörningarMetabolic DiseasesÄmnesomsättningssjukdomarNutritional and Metabolic DiseasesNäringsrubbningar och ämnesomsättningssjukdomar Plants and animalsVäxter och djurClinical ScienceKlinisk vetenskapVeterinary ScienceVeterinärmedicinNATURAL ENVIRONMENTNATUR OCH MILJÖAgricultural and Veterinary sciencesLantbruksvetenskap och veterinärmedicin Feline diabetes mellitus shares many features with type 2 diabetes in people, regarding clinical presentation, physiology, and pathology. A breed predisposition for type 2 diabetes has been identified, with the Burmese breed at a fivefold increased risk of developing the condition compared to other purebred cats. We aimed to characterize the serum metabolome in cats (n = 63) using nuclear magnetic resonance metabolomics, and to compare the metabolite pattern of Burmese cats with that of two cat breeds of medium or low risk of diabetes, the Maine coon (MCO) and Birman cat, respectively. Serum concentrations of adiponectin, insulin and insulin-like growth factor-1 were also measured (n = 94). Burmese cats had higher insulin and lower adiponectin concentrations than MCO cats. Twenty one metabolites were discriminative between breeds using a multivariate statistical approach and 15 remained significant after adjustment for body weight and body condition score. Burmese cats had higher plasma levels of 2-hydroxybutyrate relative to MCO and Birman cats and increased concentrations of 2-oxoisocaproic acid, and tyrosine, and lower concentrations of dimethylglycine relative to MCO cats. The metabolic profile of MCO cats was characterized by high concentrations of arginine, asparagine, methionine, succinic acid and low levels of acetylcarnitine while Birman cats had the highest creatinine and the lowest taurine plasma levels, compared with MCO and Burmese. The pattern of metabolites in Burmese cats is similar to that in people with insulin resistance. In conclusion, the metabolic profile differed between healthy cats of three breeds. Detection of an abnormal metabolome might identify cats at risk of developing diabetes. The study was approved by the ethics committee on animal experiments in Uppsala, reference number C 299/12 and C 12/15, and by the Swedish Board of Agriculture, reference number 31-11654/12. Results from analysis of blood samples from healthy cats of three breeds: Burmese, Birman and Maine coon, are included. A clinical examination was performed on the cats and information noted. Hormones were analysed in serum using immunological methods. Lipoproteins were analysed using HPLC (high performance liquid chromatography) and metabolomics using NMR (nuclear magnetic resonance) spectroscopy.Studien beskriver metabolomet hos tre kattraser med olika hög risk att utveckla diabetes mellitus. Se vidare engelsk sammanfattning. Studien godkändes av Uppsala Djurförsöksetiska nämnd, diarienummer C 299/12 och C 12/15, samt av Jordbruksverket, diarienummer 31-11654/12. Blodprov har tagits från friska katter av tre raser; burma, birma och maine coon. Katterna har undersökts kliniskt och uppgifter om dem har noterats. Serum har analyserats avseende hormoner med immunologiska metoder, lipoproteiner har analyserats med HPLC (high performance liquid chromatography) och metabolomics studerades med NMR-spektroskopi (nuclear magnetic resonance spectroscopy). 20132015 SwedenSverige IndividualIndivid Cross-sectionTvärsnitt OtherÖvrigt Access to data through SND. Data are freely accessible.Åtkomst till data via SND. Data är fritt tillgängliga. https://snd.gu.se 2021-58-1 2021-10-25T15:13:11Z ddi:codebook:2_5